{"id":10,"date":"2023-06-19T19:13:25","date_gmt":"2023-06-19T23:13:25","guid":{"rendered":"https:\/\/hougroup.xyz\/?page_id=10"},"modified":"2024-02-16T12:44:30","modified_gmt":"2024-02-16T17:44:30","slug":"research","status":"publish","type":"page","link":"https:\/\/hougroup.xyz\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"10\" class=\"elementor elementor-10\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f8348e5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f8348e5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-1bbb10a\" data-id=\"1bbb10a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45545e4 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"45545e4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.12.2 - 23-04-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"960\" height=\"458\" src=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-4.55.45-PM-1024x488.png\" class=\"attachment-large size-large wp-image-394\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-4.55.45-PM-1024x488.png 1024w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-4.55.45-PM-300x143.png 300w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-4.55.45-PM-768x366.png 768w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-4.55.45-PM-1536x733.png 1536w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-4.55.45-PM-2048x977.png 2048w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-7ff4b26\" data-id=\"7ff4b26\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-423f827 elementor-widget elementor-widget-text-editor\" data-id=\"423f827\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.12.2 - 23-04-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<h3 style=\"font-family: var( --e-global-typography-primary-font-family ), Sans-serif; font-weight: var( --e-global-typography-primary-font-weight ); letter-spacing: normal; color: var( --e-global-color-primary );\" data-elementor-setting-key=\"title_text\" data-elementor-inline-editing-toolbar=\"none\" data-pen-placeholder=\"Type Here...\">Overview<\/h3><p>We are interested in modeling biological systems across different scales, providing insights into diseases mechanisms and empowering precision medicine.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9bd22ae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9bd22ae\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-44cfd9c\" data-id=\"44cfd9c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-306be58 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"306be58\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"642\" height=\"634\" src=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-5.13.38-PM.png\" class=\"attachment-large size-large wp-image-396\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-5.13.38-PM.png 642w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/09\/Screen-Shot-2023-09-13-at-5.13.38-PM-300x296.png 300w\" sizes=\"(max-width: 642px) 100vw, 642px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2faf630\" data-id=\"2faf630\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-947969e elementor-widget elementor-widget-text-editor\" data-id=\"947969e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3 class=\"elementor-image-box-title elementor-inline-editing pen\" style=\"font-family: var( --e-global-typography-primary-font-family ), Sans-serif; font-weight: var( --e-global-typography-primary-font-weight ); letter-spacing: normal; color: var( --e-global-color-primary );\" data-elementor-setting-key=\"title_text\" data-elementor-inline-editing-toolbar=\"none\" data-pen-placeholder=\"Type Here...\">Understanding patients&#8217; heterogeneity by joint learning of phenotypic data and oimcs data<\/h3><p>A key challenge in addressing complex diseases lies in the considerable heterogeneity observed across patients and the temporal variability within individuals. We integrate\u00a0 omics data (<span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">gene expression,<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">\u00a0<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">ATAC-seq, histone modification, DNA methylation, etc.), and medical data including medical imaging, electrical health record (EHR) to 1) investigate disease subtyping or staging and discover biomarkers; 2) prioritize potential intervention strategies for different subtypes or stages. We are particular interested in brain diseases including Alzheimer&#8217;s disease and psychiatric diseases.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4e5cc40 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4e5cc40\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-b64c253\" data-id=\"b64c253\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4e818e5 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"4e818e5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"469\" height=\"582\" src=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/06\/Direct1.png\" class=\"attachment-large size-large wp-image-193\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/06\/Direct1.png 469w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/06\/Direct1-242x300.png 242w\" sizes=\"(max-width: 469px) 100vw, 469px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-bf5fe46\" data-id=\"bf5fe46\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50bd798 elementor-widget elementor-widget-text-editor\" data-id=\"50bd798\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3 class=\"elementor-image-box-title elementor-inline-editing pen\" style=\"font-family: var( --e-global-typography-primary-font-family ), Sans-serif; font-weight: var( --e-global-typography-primary-font-weight ); letter-spacing: normal; color: var( --e-global-color-primary );\" data-elementor-setting-key=\"title_text\" data-elementor-inline-editing-toolbar=\"none\" data-pen-placeholder=\"Type Here...\">A multi-context view of cellular states<\/h3><p><span style=\"white-space-collapse: preserve;\">While a cellular state is largely defined by the differentiation stage, it is also impacted by environmental stimuli through intercellular signaling pathways. We charts a multi-context view of cellular states of different cell types by building context-specific transcription factor (TF)\/enhancer\/gene (TEG) networks, where different contexts include differentiation, tissue-specific microenvironment, inflammatory response, and others. <\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f553859 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f553859\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1ede5f0\" data-id=\"1ede5f0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ae926c7 elementor-widget elementor-widget-image\" data-id=\"ae926c7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"455\" height=\"361\" src=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/06\/Direct2.png\" class=\"attachment-large size-large wp-image-194\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/06\/Direct2.png 455w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2023\/06\/Direct2-300x238.png 300w\" sizes=\"(max-width: 455px) 100vw, 455px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-bf8e091\" data-id=\"bf8e091\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-88e6c99 elementor-widget elementor-widget-text-editor\" data-id=\"88e6c99\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3 class=\"elementor-image-box-title elementor-inline-editing pen\" style=\"font-family: var( --e-global-typography-primary-font-family ), Sans-serif; font-weight: var( --e-global-typography-primary-font-weight ); letter-spacing: normal; color: var( --e-global-color-primary );\" data-elementor-setting-key=\"title_text\" data-elementor-inline-editing-toolbar=\"none\" data-pen-placeholder=\"Type Here...\">Context-specific impact of genetic variants<\/h3><p><span style=\"white-space-collapse: preserve;\">Current efforts in the context-specific functional dissection for disease-associated genetic variants rely on joint modeling GWAS signal and available context-specific epigenomic annotations, QTL mapping or perturbation assays (CRISPR or MPRA). However, there is still a lack of studies that systematically model impact of genetic variants in TF-Enhancer-Gene (TEG) networks, and cellular states levels across conditions. We investigate the impact of genetic variants over TEG networks, the basis to infer disease-driving context-specific TEG networks.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b0321f1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b0321f1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-242f9dd\" data-id=\"242f9dd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f996593 elementor-widget elementor-widget-image\" data-id=\"f996593\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"960\" height=\"720\" src=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2024\/02\/2024.1.27.May_-scaled-e1708105299374-1024x768.jpg\" class=\"attachment-large size-large wp-image-420\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/hougroup.xyz\/wp-content\/uploads\/2024\/02\/2024.1.27.May_-scaled-e1708105299374-1024x768.jpg 1024w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2024\/02\/2024.1.27.May_-scaled-e1708105299374-300x225.jpg 300w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2024\/02\/2024.1.27.May_-scaled-e1708105299374-768x576.jpg 768w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2024\/02\/2024.1.27.May_-scaled-e1708105299374-1536x1152.jpg 1536w, https:\/\/hougroup.xyz\/wp-content\/uploads\/2024\/02\/2024.1.27.May_-scaled-e1708105299374-2048x1536.jpg 2048w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1edde70\" data-id=\"1edde70\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-54d90e0 elementor-widget elementor-widget-text-editor\" data-id=\"54d90e0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h3 style=\"font-family: var( --e-global-typography-primary-font-family ), Sans-serif; font-weight: var( --e-global-typography-primary-font-weight ); letter-spacing: normal; color: var( --e-global-color-primary );\" data-elementor-setting-key=\"title_text\" data-elementor-inline-editing-toolbar=\"none\" data-pen-placeholder=\"Type Here...\">Project X: animal intelligence and well-being<\/h3>\n<p><span style=\"white-space-collapse: preserve;\">We are currently training an animal intelligence (AI) model at home with a multi-modality (speaking, feeding, smelling, patting, &#8230; ) framework, aiming to study how pet companion impacts both mental and physical healthy longitudinally \ud83d\ude42<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Overview We are interested in modeling biological systems across different scales, providing insights into diseases mechanisms and empowering precision medicine. Understanding patients&#8217; heterogeneity by joint learning of phenotypic data and<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research - Hou Group Of Systems Genomics and Genetics<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hougroup.xyz\/index.php\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Hou Group Of Systems Genomics and Genetics\" \/>\n<meta property=\"og:description\" content=\"Overview We are interested in modeling biological systems across different scales, providing insights into diseases mechanisms and empowering precision medicine. 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